DHEA cream can be really beneficial for correcting hormone levels and negating the effects of menopause or andropause. However, there can be a bit of a learning curve when you first start using it. Here are some questions patients often have when they first start using DHEA cream. Can you apply the cream somewhere other than the recommended areas? If you read the instructions on your DHEA cream, they likely specify that the product needs to be applied to your forearms or your rib cage.